Dual appointments in Biological Engineering and Medical Engineering
Research Group Manager: Natasha Shelby
Members of Ismagilov Group have backgrounds in chemistry, biology, engineering, medicine, and biophysics—creating a rich, interdisciplinary environment in which to solve real-world problems. Uniting the group's diverse interests is a commitment to improve global health, specifically via their work on the human microbiome and in vitro diagnostics.
Ismagilov Lab has pioneered the development of microfluidic technologies (including droplet-based microfluidics and SlipChip). Microfluidics enables ultrasensitive, quantitative biomarker measurements, and provides tools with which to control and understand the dynamics of complex chemical and biological networks. Such capabilities are poised to revolutionize medicine—enabling rapid point-of-care diagnoses under a variety of settings outside of centralized clinical laboratories. Currently, the group is applying these innovative technologies to develop rapid diagnostics of antimicrobial susceptibility. In the context of the human microbiome, the lab works to understand host-microbe interactions that may lead to new therapeutics. These technologies are also enabling new single-molecule measurements and single-cell analyses.
Publications
- Wu-Woods, Natalie J.;Barlow, Jacob T. et al. (2023) Microbial-enrichment method enables high-throughput metagenomic characterization from host-rich samplesNature Methods
- Ji, Jenny;Viloria Winnett, Alexander et al. (2023) Index cases first identified by nasal-swab rapid COVID-19 tests had more transmission to household contacts than cases identified by other test typesPLOS ONE
- Poceviciute, Roberta;Bogatyrev, Said R. et al. (2023) Quantitative whole-tissue 3D imaging reveals bacteria in close association with mouse jejunum mucosanpj Biofilms and Microbiomes
- Winnett, Alexander Viloria;Akana, Reid et al. (2023) Daily SARS-CoV-2 Nasal Antigen Tests Miss Infected and Presumably Infectious People Due to Viral Load Differences among Specimen TypesMicrobiology Spectrum
- Ji, Jenny;Winnett, Alexander Viloria et al. (2023) Index Cases First Identified by Nasal-Swab Rapid COVID-19 Tests Had More Transmission to Household Contacts Than Cases Identified by Other Test Types
- Winnett, Alexander Viloria;Akana, Reid et al. (2023) Extreme differences in SARS-CoV-2 viral loads among respiratory specimen types during presumed pre-infectious and infectious periodsPNAS Nexus
- Carter, Alyssa M.;Winnett, Alexander Viloria et al. (2023) Laboratory Evaluation Links Some False-Positive COVID-19 Antigen Test Results Observed in a Field Study to a Specific Lot of Test StripsOpen Forum Infectious Diseases
- Earley, Zachary M.;Lisicka, Wioletta et al. (2023) GATA4 controls regionalization of tissue immunity and commensal-driven immunopathologyImmunity
- Winnett, Alexander Viloria;Porter, Michael K. et al. (2022) Morning SARS-CoV-2 Testing Yields Better Detection of Infection Due to Higher Viral Loads in Saliva and Nasal Swabs upon WakingMicrobiology Spectrum
- Winnett, Alexander Viloria;Akana, Reid et al. (2022) Why Daily SARS-CoV-2 Nasal Rapid Antigen Testing Poorly Detects Infected and Infectious Individuals